Researchers in the Cardiovascular Modelling and Instruments Laboratory are mainly interested in electromechanical phenomena.
Jonathan B. Béland, MSc
Doctoral Student in Physiology, Université de Montréal
jonathan.boudreau-Beland@icm-mhi.org, extension 2616
Development of a system that integrates electrical and mechanical stimulation to produce replacement cardiac tissue that is optimized through tissue engineering. Cardiac remodelling study: modulation of stretch-activated ion channels in the neonatal cardiomyocytes of rats. Analysis of protein levels using a western blot based on substrate rigidity, electrical stimulation and mechanical stimulation. Imaging with video microscopy and confocal microscopy. Pharmacological effect on autonomic cardiac activity. Service for the design of customized parts using SolidWorks and 3D printing.
James Elber Duverger, BEng
Doctoral Student in Biomedical Engineering, Université de Montréal
james-elber.duverger@polymtl.ca, extension 2708
James is passionate about anything related to biosignals, from the development of measuring instruments to biological mathematical models and analysis software. He designed a device to measure the electrical response of stretched cardiac cells; he also created analysis software under Matlab (action potentials, calcium transients and video microscopy) which he uses in other laboratories. His affinity for the open source movement has also made him active in this field. He is currently working on the modelling of biological pacemakers to more efficiently treat patients suffering from bradycardia (slow heart rate).
Martin Aguilar, MD
Doctoral Student in Physiology
Université de Montréal
martin.aguilar@mail.mcgill.ca
Martin is a medical resident in internal medicine who is interested in cardiac electrophysiology. His research in the laboratories of Dr. Nattel and Dr. Comtois focuses in part on modelling antiarrhythmia drugs for atrial fibrillation (AF) to better understand the optimal properties that these agents should have in order to maximize the termination of AF while minimizing their ventricular proarrhythmic properties.
- Development of a bioreactor to culture “pacemaker” layers through tissue engineering and the study of cellular remodelling.
- Mathematical modelling of autonomic electrical activity and study of cellular remodelling on cell rhythm in in-silico tissues.
- Mathematical modelling of AF and antiarrhythmics.
- Study of microdeformation and its role in AF.
- Development of systems to measure cellular force with fibre optics (in collaboration with Tactus Scientific, Montréal).
Pubmed : Philippe Comtois
Team members
Jonathan B. Béland, MSc
Doctoral Student in Physiology, Université de Montréal
jonathan.boudreau-Beland@icm-mhi.org, extension 2616
Development of a system that integrates electrical and mechanical stimulation to produce replacement cardiac tissue that is optimized through tissue engineering. Cardiac remodelling study: modulation of stretch-activated ion channels in the neonatal cardiomyocytes of rats. Analysis of protein levels using a western blot based on substrate rigidity, electrical stimulation and mechanical stimulation. Imaging with video microscopy and confocal microscopy. Pharmacological effect on autonomic cardiac activity. Service for the design of customized parts using SolidWorks and 3D printing.
James Elber Duverger, BEng
Doctoral Student in Biomedical Engineering, Université de Montréal
james-elber.duverger@polymtl.ca, extension 2708
James is passionate about anything related to biosignals, from the development of measuring instruments to biological mathematical models and analysis software. He designed a device to measure the electrical response of stretched cardiac cells; he also created analysis software under Matlab (action potentials, calcium transients and video microscopy) which he uses in other laboratories. His affinity for the open source movement has also made him active in this field. He is currently working on the modelling of biological pacemakers to more efficiently treat patients suffering from bradycardia (slow heart rate).
Martin Aguilar, MD
Doctoral Student in Physiology
Université de Montréal
martin.aguilar@mail.mcgill.ca
Martin is a medical resident in internal medicine who is interested in cardiac electrophysiology. His research in the laboratories of Dr. Nattel and Dr. Comtois focuses in part on modelling antiarrhythmia drugs for atrial fibrillation (AF) to better understand the optimal properties that these agents should have in order to maximize the termination of AF while minimizing their ventricular proarrhythmic properties.
Research projects
- Development of a bioreactor to culture “pacemaker” layers through tissue engineering and the study of cellular remodelling.
- Mathematical modelling of autonomic electrical activity and study of cellular remodelling on cell rhythm in in-silico tissues.
- Mathematical modelling of AF and antiarrhythmics.
- Study of microdeformation and its role in AF.
- Development of systems to measure cellular force with fibre optics (in collaboration with Tactus Scientific, Montréal).
Publications
Pubmed : Philippe Comtois