Our research efforts may eventually lead to better tools for diagnosis and prevention and more effective treatments. Many research projects now under way have already used the Biobank’s resources. A list of these fascinating projects is given below.
To make a scientific contribution to this work and collaborate with our researchers, please consult the Researchers section.
- Genetic and molecular aspects of aortic valve stenosis
- ACS Genomic Study
- Sequencing of genes associated with myocardial infarction
- Identification of genes responsible for MI and for Sudden Cardiac Death
- Accuracy of pharmacogenetic algorithms to predict warfarin initial dose and genetic predictors of INR fluctuations in patients treated with warfarin
- Whole-exome/-genome re-sequencing of patients with extreme cardiovascular-related phenotypes of unknown genetic etiology
- Personnalizing the interpretation of N-Terminal proB-Type natriuretic peptide concentrations in patients without cardiac diseases through the incorporation of genetic information
- Does experiencing psychological distress make you age faster? (BEL-AGE)
- Descriptive analysis of the data recorded in the hospital cohort (CohorteStat10K)
- Genetic study of cardiovascular disease in the MHI hospital cohort (EXOME CHIP)
- Validation of nutrient intake of participants in the MHI biobank through the use of blood biomarkers (DIETBIOMAKER)
- Echocardiographic predictors of development and progression of aortic valve stenosis
- Genomic determinants and pharmacogenomic markers of heart failure in the Montreal Heart Institute Genetic Cohort (GIANT)
- Study of plasma biomarkers of cardiovascular risk in the CAIN study (CAIN-003) – Is the activity of lecithin: cholesterol acyltransferase (LCAT) associated with HDL is different between Biobank control subjects and coronary patients from CAIN project?
- Genetic and functional characterization of HDL
- Validation of the association between a coding mutation in PSCR1 and ApoB and other circulating lipid levels
Genetic and molecular aspects of aortic valve stenosis
Project: #08-1075
Principal investigator: J-C Tardif, M.D.
Collaborators: J.D. Rioux, É. Rhéaume, C. Eyendja, M. Balasescu
ACS Genomic Study
Project: #08-1083
Principal investigator: J-C Tardif, M.D.
Collaborators: M. Phillips, J.D. Rioux, M-P. Dubé
Sequencing of genes associated with myocardial infarction
Project: #09-1112
Principal investigator: G. Lettre, Ph.D.
Collaborators: J-C. Tardif, J.D. Rioux, M.Phillips
Identification of genes responsible for MI and for Sudden Cardiac Death
Project: #09-1145
Principal investigator: J-C Tardif, M.D.
Collaborators: J.D. Rioux, M-P. Dubé, G. Lettre, M. Phillips, P. Goyette
Accuracy of pharmacogenetic algorithms to predict warfarin initial dose and genetic predictors of INR fluctuations in patients treated with warfarin
Project: #09-1178
Principal investigator: M-P Dubé, Ph.D.
Collaborators: J-C. Tardif, M. Talajic, N. Laplante, M. Phillips
Whole-exome/-genome re-sequencing of patients with extreme cardiovascular-related phenotypes of unknown genetic etiology
Project: #10-1205
Principal investigator: G. Lettre, Ph.D.
Collaborators: J.D. Rioux, JC Tardif, P. Khairy, L. Robb, N. Racine, M. Talajic, N. Laplante
Personnalizing the interpretation of N-Terminal proB-Type natriuretic peptide concentrations in patients without cardiac diseases through the incorporation of genetic information
Project: #11-1267
Principal investigator: S. de Denus, MSc, Ph.D.
Collaborators: M. Phillips, M-P. Dubé, M. White, J-C. Tardif, B. D’Antono
Does experiencing psychological distress make you age faster? (BEL-AGE)
Project: #11-1313
Principal investigator: B. D'Antono, Ph.D.
Collaborators: L. Busque, M-P. Dubé, S. Perreault, J-C. Tardif.
Descriptive analysis of the data recorded in the hospital cohort (CohorteStat10K)
Project: #11-1324
Principal investigator: M-P Dubé, Ph.D.
Collaborators: J-C. Tardif, S. de Denus, B. D’Antono, J. Brunet, J-C. Tardif
Genetic study of cardiovascular disease in the MHI hospital cohort (EXOME CHIP)
Project: #11-1333
Principal investigator: J-C Tardif, M.D.
Collaborators: M-P. Dubé, S. de Denus, B. D’Antono, M. Philips, J.D. Rioux, G. Lettre.
Validation of nutrient intake of participants in the MHI biobank through the use of blood biomarkers (DIETBIOMAKER)
Project: #12-1411
Principal investigator: G. Lettre, Ph.D.
Collaborators: C. Des Rosiers, V.Turcot
Echocardiographic predictors of development and progression of aortic valve stenosis
Project: #12-1409
Principal investigator: J-C Tardif, M.D.
Collaborators: É. Rhéaume, B. Arsenault, D. Rhainds, A. Benjamim de Oliveira Moraes, M-P. Dubé, D. Busseuil
Genomic determinants and pharmacogenomic markers of heart failure in the Montreal Heart Institute Genetic Cohort (GIANT)
Project: #13-1421
Principal investigator: S. de Denus, MSc, Ph.D.
Collaborators: M-P. Dubé, M. White, E. O’Meara, M. Liszkowski, A. Ducharme, N.Racine, J-L. Rouleau, J-C. Tardif
Study of plasma biomarkers of cardiovascular risk in the CAIN study (CAIN-003) – Is the activity of lecithin: cholesterol acyltransferase (LCAT) associated with HDL is different between Biobank control subjects and coronary patients from CAIN project?
Project: #13-1426
Principal investigator: J-C Tardif, M.D.
Collaborators: D. Rhainds, É. Rhéaume, É. Kritikou, G. He.
Genetic and functional characterization of HDL
Project: #13-1438
Principal investigator: J-C Tardif, M.D.
Collaborators: G. Lettre, M-P Dubé, É. Rhéaume, D. Rhainds
Validation of the association between a coding mutation in PSCR1 and ApoB and other circulating lipid levels
Project: #13-1448
Principal investigator: G. Lettre, Ph.D.
Collaborators: