Description of the vascular field
In this field, both physiological and pathological vascular function is studied under a wide variety of aspects, from genetics to major clinical trials. Researchers in this field aim to understand biological mechanisms; develop treatment, diagnostic and prevention methods in the fields of atherosclerosis, myocardial infarction, inflammation, vascular remodelling, angiogenesis, and interactions between vessel walls and the formed elements of blood; and assess the impact of cardiovascular disease risk factors, including aging.
Our researchers use cutting-edge technology to study processes on the molecular and cellular levels (e.g., in vivo gene inactivation, multimodal imaging and multimodal DNA sequencing) and also employ varied and often unique animal models to study systems biology.
When combined with genetics, these approaches, which involve screening the genomes and proteomes and identifying the metabolomics of patients with vascular disease who have been extensively phenotyped, provide new biomarkers and new biological targets that can be functionally explored.
Researchers in the vascular field
Description of the electrophysiology field
The cardiovascular electrophysiology research field deploys a range of complementary methods to address problems related to the control of the electrophysiological systems of the heart and vessels. Research in this field is mainly conducted on atrial fibrillation and ventricular fibrillation. Each area within the field is organized to include new interventional approaches, pharmacological prevention/treatment methods, and physiopathology.
In all cases, there is extensive complementarity between clinical research and basic research. The general goals are to better understand the electrical function of the heart and vessels to better combat the consequences of their dysfunction.
Researchers in the electrophysiology field
Description of the myocardial field
Cardiac function (and dysfunction) is the central subject of the myocardial field. Researchers examine cardiac function through basic research and major clinical trials. Basic and clinical research in this field therefore targets a central goal: improve the treatment, prevention, diagnosis and prognosis of heart failure and related conditions (fields), such as right and left ventricular systolic and diastolic dysfunction, acquired or congenital cardiomyopathy, ventricular hypertrophy, perioperative myocardial protection, perioperative pulmonary hypertension, heart transplants, implantation of ventricular assist devices, regenerative therapy, and heart failure related to valve disease. The scientific goals of this field are in line with traditional research subjects and new contributions of the Centre's cross-disciplinary scientific approaches.
Researchers in the myocardial field
Description of the vascular field
In this field, both physiological and pathological vascular function is studied under a wide variety of aspects, from genetics to major clinical trials. Researchers in this field aim to understand biological mechanisms; develop treatment, diagnostic and prevention methods in the fields of atherosclerosis, myocardial infarction, inflammation, vascular remodelling, angiogenesis, and interactions between vessel walls and the formed elements of blood; and assess the impact of cardiovascular disease risk factors, including aging.
Our researchers use cutting-edge technology to study processes on the molecular and cellular levels (e.g., in vivo gene inactivation, multimodal imaging and multimodal DNA sequencing) and also employ varied and often unique animal models to study systems biology.
When combined with genetics, these approaches, which involve screening the genomes and proteomes and identifying the metabolomics of patients with vascular disease who have been extensively phenotyped, provide new biomarkers and new biological targets that can be functionally explored.
Researchers in the vascular field
Description of the electrophysiology field
The cardiovascular electrophysiology research field deploys a range of complementary methods to address problems related to the control of the electrophysiological systems of the heart and vessels. Research in this field is mainly conducted on atrial fibrillation and ventricular fibrillation. Each area within the field is organized to include new interventional approaches, pharmacological prevention/treatment methods, and physiopathology.
In all cases, there is extensive complementarity between clinical research and basic research. The general goals are to better understand the electrical function of the heart and vessels to better combat the consequences of their dysfunction.
Researchers in the electrophysiology field
Description of the myocardial field
Cardiac function (and dysfunction) is the central subject of the myocardial field. Researchers examine cardiac function through basic research and major clinical trials. Basic and clinical research in this field therefore targets a central goal: improve the treatment, prevention, diagnosis and prognosis of heart failure and related conditions (fields), such as right and left ventricular systolic and diastolic dysfunction, acquired or congenital cardiomyopathy, ventricular hypertrophy, perioperative myocardial protection, perioperative pulmonary hypertension, heart transplants, implantation of ventricular assist devices, regenerative therapy, and heart failure related to valve disease. The scientific goals of this field are in line with traditional research subjects and new contributions of the Centre's cross-disciplinary scientific approaches.
Researchers in the myocardial field