Dr. Gaétan Mayer

Title(s), professional position(s) and university affiliation(s): 

Director, Cellular and Molecular Biology Laboratory MHI
Research Assistant Professor, Department of Medicine, Université de Montréal

Dr Gaetan Mayer

Since 2010, Dr. Gaétan Mayer is a professor at Université de Montréal and the director of the Cellular and Molecular Biology Laboratory at the Montreal Heart Institute (MHI). His work focuses on the study of the mechanisms that control blood cholesterol, which is a major source of atherosclerosis and cardiovascular disease. His laboratory is interested in characterizing the mechanism of action of proprotein convertases, such as PCSK9, that trigger an increase in "bad" cholesterol in humans and the role of these enzymes in the etiology of metabolic syndrome. Moreover, Dr. Mayer's laboratory is also conducting research on factors that influence PCSK9 activity, triglyceride metabolism, and progression of atherosclerosis. These studies aim to develop innovative therapeutic approaches and use them in human health to treat hypercholesterolemia and decrease deaths due to cardiovascular diseases.

These studies are funded by the Canadian Institutes of Health Research (CIHR), the Heart and Stroke Foundation of Canada and Québec (HSFC, HSFQ), the Fonds de la recherche du Québec – Santé (FRQS), the Canada Foundation for Innovation (CFI) and the MHI Foundation.

Research interest(s) 
  • Atherosclerosis
  • Cardiovascular disease
  • Familial hypercholesterolemia
  • PCSK9
  • Low-density lipoprotein (LDL)
  • LDL receptor (LDLR)
  • Transcriptional regulation
  • Protein trafficking
  • Cholesterol
  • Triglycerides
  • Metabolic syndrome
  • CD36
  • Golgi apparatus
  • Lysosomes
  • Adipose tissue
  • Obesity
Awards and Distinctions 

2016: Clinical Research Scholar, Junior 2, FRQS
2011 : Clinical Research Scholar, Junior 1, FRQS
2011 : Jonathan-Ballon Award for young researchers, Heart and Stroke Foundation of Canada and Québec
2011-2014 : CIHR-INMD new researcher seed grant
2008 : Postdoctoral fellow award, Cardiovascular Diseases. Canadian Lipoprotein Conference/Pfizer. 
2005 : Doctoral thesis, Dean's Honour List, Pathology and Cell Biology. Faculty of Medicine, Université de Montréal
2000 : Academic Medal (Gold), outstanding scholastic achievements. Governor General of Canada

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